Impaired Keratinocyte Proliferative And Clonogenic Potential In Transgenic Mice Overexpressing 14-3-3σ In The Epidermis

    June 2011 in “ Journal of Investigative Dermatology ”
    Francesca Cianfarani, Silvia Bernardini, Naomi De Luca, Elena Dellambra, Laura Tatangelo, Cecilia Tiveron, Carien M. Niessen, Giovanna Zambruno, Daniele Castiglia, Teresa Odorisio
    TLDR Overexpressing 14-3-3σ in mice skin reduces cell growth and hair density.
    In this study, transgenic mice overexpressing 14-3-3σ in the epidermis showed decreased keratinocyte proliferation and clonogenic potential, leading to reduced epidermal thickness and hair follicle density. The overexpression resulted in a decrease in keratinocyte progenitor cell numbers and impaired response to IGF-1, affecting downstream mediators like PI3K, AKT, and Rac1. Various assays revealed reduced keratinocyte motility and colony-forming capacity in transgenic mice compared to wild-type controls. The study suggested that 14-3-3σ played a role in controlling the epidermal proliferation-differentiation switch by promoting cell cycle exit in keratinocytes, highlighting its potential tumor suppressor function and impact on IGF-1-mediated signaling pathways.
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