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GlossaryTumor Suppressor Gene

regulates cell growth by preventing uncontrolled cell division

A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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research Independent Genomewide Screens Identify the Tumor Suppressor VTRNA2-1 as a Human Epiallele Responsive to Periconceptional Environment

153 citations, June 2015 in “GenomeBiology.com”

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

81 citations, November 2012 in “Journal of the National Cancer Institute”

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

research The Vitamin D Receptor as Tumor Suppressor in Skin

55 citations, January 2020 in “Advances in experimental medicine and biology”

Vitamin D and its receptor may help prevent skin cancer.

research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation

44 citations, September 2014 in “Cell Death & Differentiation”

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

37 citations, January 2006 in “Carcinogenesis”

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 38 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Pyrilutamide 5 months results (before, after pics)

in Progress Pictures 193 upvotes 1 year ago

Tae147 has shared results of using pyrilutamide, a 5% concentration topical solution applied twice daily, in combination with minoxidil, to reduce scalp itchiness and hair shedding. Other users have shared their experiences with the treatment, as well as questions about its availability on the market.

community Testosterone and hair loss seeming irrelevance

in Research/Science 81 upvotes 1 year ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Goodbye y'all, it's been a journey but have accepted where I'm at

in Update 219 upvotes 1 year ago

The conclusion of this conversation about hair loss is that the user, y00sh420, tried various treatments including a $700 lllt helmet, topical minoxidil and finasteride, spectraDNC, and micro needling, but did not achieve the desired results. They have decided to stop trying until a cure for male pattern baldness is found. Other users expressed different opinions on hair loss treatments.

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