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    Did you mean Tumor Suppressor Gene?
    Glossary Tumor Suppressor Gene

    regulates cell growth by preventing uncontrolled cell division

    A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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    Research 30 of 1000+

    1. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment GenomeBiology.com · 2015 · 153 citations
    2. Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN Journal of the National Cancer Institute · 2012 · 81 citations
    3. Stem cell quiescence acts as a tumour suppressor in squamous tumours Nature Cell Biology · 2013 · 66 citations
    4. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020 · 55 citations
    5. Roles of tumor suppressors in regulating tumor-associated inflammation Cell Death & Differentiation · 2014 · 44 citations
    6. Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis Carcinogenesis · 2006 · 37 citations
    7. Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma Experimental Dermatology · 2016 · 8 citations
    8. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    9. The Tumor Suppressor Actions of the Vitamin D Receptor in Skin 2014 · 9 citations
    10. The Tumor Suppressor Actions of the Vitamin D Receptor in Skin 2013
    11. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    12. Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor The Journal of Clinical Endocrinology & Metabolism · 1997 · 19 citations
    13. Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice International journal of molecular sciences · 2020 · 1 citations
    14. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion PloS one · 2012 · 72 citations
    15. Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors Cancer Research · 2008 · 64 citations
    16. The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis Molecular Carcinogenesis · 2008 · 10 citations
    17. Data from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors 2023
    18. Data from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors 2023
    19. A new way to restore tumour suppressor function Nature Reviews Drug Discovery · 2013
    20. 410 NON-INVASIVE DIAGNOSIS OF PROSTATE CANCER FROM BODY FLUIDS USING A PANEL OF TUMOR SUPPRESSOR GENES European Urology Supplements · 2011
    21. 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma Journal of Investigative Dermatology · 2016 · 1 citations
    22. The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor Tumor Biology · 2021 · 16 citations
    23. Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice Journal of Biological Chemistry · 2004 · 91 citations
    24. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis Development · 2007 · 28 citations
    25. The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs) Proteomes · 2023 · 4 citations
    26. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    27. Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database PLoS ONE · 2022 · 16 citations
    28. Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo PLoS ONE · 2025
    29. Cylindroma as Tumor of Hair Follicle Origin Journal of Investigative Dermatology · 2006 · 57 citations
    30. Supplemental figure 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate 2023