Knockout of the ING5 Epigenetic Regulator Confirms Roles in Stem Cell Maintenance and Tumor Suppression In Vivo

    January 2025 in “ PLoS ONE ”
    Buthaina Al Shueili, Arthur Dantas, Etienne Mahé, Tak‐Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand O. Masson, Hiba Omairi, Kenichi Ito, Roman Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol
    TLDR ING5 is crucial for stem cell maintenance and preventing certain cancers.
    The study explores the role of the ING5 gene in stem cell maintenance and tumor suppression using CRISPR/Cas9 knockout mice. ING5 knockout mice exhibited sub-fertility, increased rates of dermatitis, and a 6-fold higher incidence of germinal centre diffuse large B-cell lymphomas by 18 months compared to controls. Despite these issues, their lifespan and wound healing were not significantly affected. The knockout mice showed reduced neural stem cell markers, increased differentiation into neurons, and fewer hair follicles after wounding, indicating disrupted stem cell regeneration. The study involved 207 ING5 knockout and 373 wild-type mice, confirming ING5's critical role in stem cell maintenance and as a tumor suppressor, particularly in hematopoietic cells.
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