TLDR Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.
The transcription factor Runx1, traditionally studied in leukemia and blood, was found to play significant roles in epithelial biology and pathology, particularly in mouse skin. It regulated Wnt signaling, influencing hair follicle development and stem cell activation. Runx1 also promoted tumor formation in mouse skin and oral epithelium, and supported growth in various human epithelial cancers, while acting as a tumor suppressor in the mouse intestine and showing subtype-specific behavior in human breast cancer. Runx1 SNPs were linked to human cancers and autoimmune diseases, suggesting the need for further studies on its role in epithelial-based human diseases.
161 citations,
October 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
759 citations,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
6 citations,
March 2006 in “Journal of dermatological science” Runx1 helps control the KAP5 gene in human hair follicles.
27 citations,
September 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers found new genes involved in hair growth, which could help develop new hair treatments.
73 citations,
November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
April 2019 in “Journal of Investigative Dermatology” Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.
