Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation

August 2005 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Yumiko Ishimatsu‐Tsuji, Osamu Moro, Jiro Kishimoto

hair cycle wax depilation gene expression hair follicle carbonic anhydrase 6 cytokeratin 12 matrix metalloproteinase-11 DNA microarray hybridization hair growth hair removal

TLDR Researchers found new genes involved in hair growth, which could help develop new hair treatments.

The study systematically analyzed gene expression patterns in mouse skin during different stages of the hair cycle induced by wax depilation using DNA microarray hybridization. Researchers identified 12 new genes specifically expressed in the hair follicle and categorized upregulated genes into four groups corresponding to different hair cycle stages. Notable genes included carbonic anhydrase 6, cytokeratin 12, and matrix metalloproteinase-11. These findings provided insights into hair cycle regulation and could lead to novel molecular targets for hair growth and depilation treatments.

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