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GlossaryKeratin 1

protein providing structural support in skin cells

Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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research Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation

27 citations, August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

research Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

1 citations, July 2021 in “IntechOpen eBooks”

Environmental factors can cause mutations in skin proteins, leading to skin disorders.

research The Relationship Between the Expression of Cytokeratin 5/6 and Clinicopathologic Factors in Invasive Breast Carcinoma

March 2010 in “Ejc Supplements”

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

research Immunohistochemical Expression of Cytokeratin 15, Cytokeratin 19, Follistatin, and Bmi-1 in Basal Cell Carcinoma

10 citations, December 2015 in “International Journal of Dermatology”

CK 15, follistatin, and Bmi-1 can help differentiate basal cell carcinoma from squamous cell carcinoma.

research Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases

2 citations, November 2020 in “The American journal of dermatopathology/American journal of dermatopathology”

Sweat duct differentiation in trichilemmal cysts is very rare and can be successfully removed with surgery.

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