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    Glossary Cytokeratins

    fibrous proteins providing structural support in epithelial cells

    Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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    1. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. PubMed · 1992 · 31 citations
    2. Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation 2005 · 27 citations
    3. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    4. An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice Current Issues in Molecular Biology · 2022 · 1 citations
    5. Decellularized Wharton's jelly matrix as a three dimensional scaffold for wound healing and hair regeneration applications KU ScholarWorks (The University of Kansas) · 2016
    6. Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells Journal of Cutaneous Pathology · 2000 · 37 citations
    7. Immunostaining study of cytokeratins in human hair follicle development 2020 · 2 citations
    8. 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma Ejc Supplements · 2010
    9. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues Differentiation · 1988 · 124 citations
    10. Expression of Plectin-1 and Trichohyalin in Human Tongue Cancer Cells Open journal of stomatology · 2018 · 2 citations
    11. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001 · 121 citations
    12. Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma International Journal of Dermatology · 2015 · 10 citations
    13. Epithelial expression of cytokeratins 15 and 19 in vitiligo Journal of Cosmetic Dermatology · 2016 · 1 citations
    14. Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases 2020 · 2 citations
    15. The pathogenesis of alopecia areata 2015
    16. Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis Journal of Cutaneous Pathology · 2017 · 7 citations
    17. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments 2000 · 91 citations
    18. Trichofolliculoma: case report with immunohistochemical study of cytokeratins 2003 · 18 citations
    19. UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO D-Scholarship@Pitt (University of Pittsburgh) · 2018
    20. The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011 · 24 citations
    21. Desmoplastic tricholemmoma in a dog Journal of veterinary medical science · 2017 · 4 citations
    22. Cutaneous Hybrid Cyst in a Sprague-Dawley Rat Journal of Toxicologic Pathology · 2012 · 1 citations
    23. Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus Autoimmunity Reviews · 2009 · 31 citations
    24. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia British Journal of Dermatology · 2009 · 54 citations
    25. Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles Journal of Cutaneous Pathology · 2011 · 14 citations
    26. Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model Frontiers in Medicine · 2025 · 8 citations
    27. Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors Annals of Dermatology · 2014 · 8 citations
    28. Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia Medicinski arhiv · 2018 · 7 citations
    29. A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? Biomedicines · 2021 · 4 citations
    30. Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker Biotechnology Letters · 2018 · 2 citations