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Glossary Mouse Skin

skin of a lab mouse used in biological research

"Mouse skin" refers to the skin of a laboratory mouse, which is often used in scientific research to study various biological processes, including hair growth, wound healing, and skin diseases. Researchers use mouse skin models because they share many similarities with human skin, allowing for controlled experiments that can provide insights into human conditions such as alopecia (hair loss) and other dermatological issues.

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Research

5 / 1000+ results

research Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair

37 citations , May 2021 in “Frontiers in Cell and Developmental Biology”

This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.

research Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

27 citations , June 2014 in “Journal of Visualized Experiments”

This protocol shows how mouse skin can be prepared as a flat mount to visualize skin structures in detail without physical sectioning.

research Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues

10 citations , June 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

This study found that cultured mouse dermal papilla (mDP) cells can induce hair follicle neogenesis in de novo regenerated skin tissues grafted onto mice.

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

November 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

In this study, Almet et al. (2023) compiled integrated single-cell RNA sequencing data from multiple mouse datasets to investigate how fibroblasts evolve during wound healing by examining changes in the extracellular matrix and signaling pathways.

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

November 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

This study does not report results but provides integrated single-cell RNA sequencing data from multiple mouse wound healing models, offering resources for studying fibroblast-driven changes in the extracellular matrix and signaling during the healing process.

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8 / 16 results

learn Osteopontin

What does osteopontin do in skin healing and inflammation? Osteopontin takes part in wound repair in mouse skin; its role in human scalp healing and inflammation has not been studied.

learn Verteporfin

Eye drug (Visudyne) that reduced scarring and let follicles re-form in mouse skin wounds; not tested or approved for hair loss in humans.

learn Lavender

Plant oil used in scalp products; hair-growth evidence is from one mouse study. It can cause skin allergy, and case reports link lavender products to breast growth in children.

learn Microneedling

Technique that makes tiny skin punctures; studied mainly as an add-on to minoxidil for pattern hair loss, with low-quality evidence. No device is FDA-cleared for hair loss.

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Follistatin

A protein that blocks activin. Mouse studies link it to the hair cycle, but it is not an approved or proven hair-loss treatment.

learn SCUBE3

Is SCUBE3 available in topical or injectable form, and how is it usually applied in studies? SCUBE3 is not available as a topical or injectable treatment and is not an approved medicine. In the one published study, the protein was microinjected into mouse skin, including skin carrying grafted human scalp follicles; there are no human clinical trials.

learn Fluocinolone

Can long-term use of Fluocinolone affect the health of hair follicles? There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.

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5 / 204 results

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 11 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community Hair and normal skin created from human pluripotent stem cells for the first time

86 upvotes 6 years ago

Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.

community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community I Guess balding is cured so should we close subreddit and move to hairstyling photos 😁 Botox-like nerve blocking reveals potential way to fully regenerate skin without scarring

6 months ago

Baldness is difficult to cure because current treatments like finasteride, dutasteride, and minoxidil only prevent hair shedding, and new developments are mostly ineffective. Botox shows potential in aiding skin regeneration and hair growth, but maintenance therapy with treatments like dutasteride and minoxidil may still be necessary.

community Another molecular pathway to promote scarless healing and regenerate hair follicles

14 upvotes 8 months ago

Carnosic acid in rosemary extract may enhance skin repair and promote hair follicle regeneration. It could be used alone or with verteporfin for scarless healing after dermal wounding.

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Related Terms

Research

research Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair

research Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

research Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

research Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.

Learn

learn Osteopontin

learn Verteporfin

learn Lavender

learn Microneedling

learn Peppermint

learn Follistatin

learn SCUBE3

learn Fluocinolone

Community Join

community Is it possible to transplant mice skin into human body?

community Hair and normal skin created from human pluripotent stem cells for the first time

community New study suggests hair regrowth on wounded and bald skin may be possible

community I Guess balding is cured so should we close subreddit and move to hairstyling photos 😁 Botox-like nerve blocking reveals potential way to fully regenerate skin without scarring

community Another molecular pathway to promote scarless healing and regenerate hair follicles

Experts

Noelle Skin

Jana Skinner

Clinics