Mouse Keratinocyte Side-Population Plays an Important Role During Malignant Progression to Skin Squamous Cell Carcinomas

    April 2012 in “ Cancer research ”
    Sun Hye Kim, Sung Hyun Lee, Marcelo L. Rodríguez‐Puebla
    TLDR Mouse skin cancer progression involves a unique group of cells marked by ABCG2 and MTS24.
    The study investigated the role of side-population (SP) cells in mouse epidermis and skin tumors, particularly in skin squamous cell carcinomas (SCCs). It found that SP cells, identified by their high drug efflux capability and elevated ABCG2/BCRP1 transporter expression, were more prevalent in SCC-derived cell lines compared to those from skin papillomas and normal epidermis. These SP cells were distinct from well-characterized hair follicle stem cells and were localized near the bulge stem cell area, expressing markers like MTS24. The findings suggested that this unique SP cell population played a significant role in the malignant progression of SCCs.
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