Runx1 Transcription Factor Is Involved in the Regulation of KAP5 Gene Expression in Human Hair Follicles

The study investigated the role of the Runx1 transcription factor in regulating the expression of the KAP5 gene in human hair follicles. Keratin-associated proteins (KAPs), particularly the ultrahigh sulfur KAP5 subfamily, are crucial components of hair fibers. The research focused on the expression of Runx1 in human hair follicles using immunohistochemical methods and examined its effect on KAP5.1 gene expression through overexpression studies in cell cultures. The findings suggested that Runx1 plays a significant role in the regulation of KAP5 gene expression, which is predominantly expressed in the cuticle layer of anagen hair follicles.