Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

    January 2004 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Michael A. Rogers, Hermelita Winter, Iris Beckmann, Jürgen Schweizer, Lutz Langbein, Silke Praetzel
    Image of study
    TLDR A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.
    The study identified a second domain of high sulfur keratin-associated protein (KAP) genes on human chromosome 21q23, comprising 16 KAP genes and two pseudogenes, categorized into KAP10 and KAP12 families. KAP10 proteins were larger and had high cysteine content, while KAP12 proteins were smaller with slightly higher cysteine content. mRNA expression of these genes was localized to the hair fiber cuticle, indicating a specialized role in hair structure. Promoter analysis revealed several enhancer elements, expanding the understanding of human KAP genes and their expression in hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 136 results

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Keratin microspheres - breakthrough

      in Research/Science  14 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  12 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Female Hair Loss, Is there anything else I should be doing?

       11 upvotes 10 years ago
      A 20-year old female experiencing hair loss, who has had normal blood tests and is currently using minoxidil as recommended by her doctor. She is asking if there are any other treatments she should consider.

    Similar Research

    5 / 1000+ results