Sequences and Differential Expression of Three Novel Human Type-II Hair Keratins

February 1997 in “ Differentiation ”

Michael A. Rogers, Hermelita Winter, Jürgen Schweizer, Lutz Langbein, Silke Praetzel, Ingrid Moll, T. Krieg

type-II hair keratins hHb3 hHb5 hHb6 cDNA amino acid sequences anagen hair follicles hair bulb lower cortex cortex keratogenous zone hair differentiation keratin expression lower matrix cells late cortical phase

Studysummary Hair differentiation starts earlier than thought, involving multiple type-II keratins.

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research Genomic Characterization of the Human Type I Cuticular Hair Keratin hHa2 and Identification of an Adjacent Novel Type I Hair Keratin Gene hHa5

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research Linkage of Monilethrix to the Trichocyte and Epithelial Keratin Gene Cluster on 12q11-q13

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research Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes

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research A cDNA Encoding the Human Type I Hair Keratin hHa1

20 citations , October 1995 in “Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression”

hHb1, hHb3, and hHb6 mRNAs start expressing at the same time in hair follicles.

research Targeted Expression of SV40 T Antigen in the Hair Follicle of Transgenic Mice Produces an Aberrant Hair Phenotype

14 citations , March 1995 in “Journal of cell science”

This study found that targeting SV40 T antigen expression to hair follicles in transgenic mice caused abnormal hair structure and hair loss, but did not lead to cell immortalization or tumor formation in follicles.

research A Gene for Monilethrix Is Closely Linked to the Type II Keratin Gene Cluster at 12q13

54 citations , January 1995 in “Human Molecular Genetics”

This study mapped monilethrix, a hereditary hair and nail disorder, to the type II keratin cluster on chromosome 12q, marking the first primary human hair disorder localization and implicating defects in "hard" keratins.

research A Novel Human Type I Hair Keratin Gene: Evidence For Two Keratin HHa3 Isoforms

21 citations , January 1995 in “Molecular Biology Reports”

This study identified a novel human type I hair keratin, hHa3-II, as an isoform of a previously described hHa3 keratin, with distinct sequence differences indicating separate gene encoding.

research Sequence and Expression of Human Hair Keratin Genes

19 citations , July 1994 in “Journal of Dermatological Science”

This study identified and characterized human hair-specific keratin genes, revealing their sequence homology with mouse counterparts and expression in hair follicle precortical cells.

research Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3

47 citations , June 1994 in “Experimental Cell Research”

mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.

research Characterization of a Hair (Wool) Keratin Intermediate Filament Gene Domain

40 citations , February 1994 in “Journal of Investigative Dermatology”

research Organization and Expression of Hair Follicle Genes

48 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.

research Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family

65 citations , February 1992 in “Development”

This study characterizes a type II keratin intermediate filament gene family involved in early sheep follicle differentiation, detailing gene expression patterns and sequences in hair cortical cells.

research Structure and Site of Expression of a Murine Type II Hair Keratin

18 citations , February 1992 in “Molecular Biology Reports”

This study identified and characterized a murine type II hair keratin, demonstrating its presence in specific cells of hair and tongue tissues.

research Chromosomal Localization of Mouse Hair Keratin Genes

21 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study suggests that hair keratin gene mutations in mice may be linked to specific loci on chromosomes 11 and 15, potentially influencing keratin expression or structure.

research Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene

27 citations , November 1991 in “Journal of Investigative Dermatology”

research Transient Expression of Mouse Hair Keratins in Transfected HeLa Cells: Interactions Between Hard and Soft Keratins

25 citations , August 1991 in “Journal of Investigative Dermatology”

research Differential Expression of Type I Hair Keratins

51 citations , March 1990 in “Journal of Investigative Dermatology”

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA

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research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)

187 citations , May 1988 in “Differentiation”

This study found that trichocytic cytokeratins, typically found in hair, are also present in nails, filiform papillae of the tongue, and the epithelial reticulum of the thymus.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

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This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins

198 citations , October 1986 in “Differentiation”