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Glossary Keratin Expression

process by which cells produce structural protein for hair and skin

Keratin expression refers to the process by which cells produce keratin, a type of protein that is a key structural component of hair, skin, and nails. This process is regulated by specific genes, and variations in keratin expression can affect the strength, texture, and growth of hair. For professionals, understanding keratin expression is crucial for diagnosing and treating conditions like alopecia and other hair disorders.

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Research

5 / 1000+ results

research Keratin expression in basal cell carcinomas

128 citations , February 1992 in “British Journal of Dermatology”

The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.

research Keratin expression in the normal nail unit: markers of regional differentiation

119 citations , January 2000 in “British Journal of Dermatology”

This study found that keratin expression patterns vary within nail unit structures, with the nail matrix uniquely expressing the acidic hair-type keratin Ha1.

research Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles

95 citations , March 2009 in “Differentiation”

Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

research Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.

94 citations , October 1994 in “The Journal of Cell Biology”

This study demonstrates that overexpression of K16 in transgenic mice disrupts normal keratinization, leading to hyperkeratosis, acanthosis, and alterations in the skin's epithelial cells.

research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

79 citations , August 1998 in “The Journal of Cell Biology”

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

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Community Join

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community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 3 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community IGF-1 and Peptides? Miracle molecule waiting to be found

10 upvotes 1 year ago

The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

community Dutasteride or treatment and TRT/PEDs

1 upvotes 1 month ago

A user experienced hair thinning after using tamoxifen and bupropion and is now using topical dutasteride, alfatradiol, melatonin, adenosine, and specific shampoos for improvement. They are considering using steroids and are seeking advice on whether combining oral dutasteride with TRT/PEDs would affect hair health, with mixed opinions on the impact of testosterone and DHT on hair loss.

community What is this pigmentation around my follicles?

in Chat 29 upvotes 1 year ago

The conversation discusses potential causes of pigmentation around hair follicles, suggesting sebum buildup, autoimmune conditions, or dermatitis. Treatments mentioned include finasteride, dutasteride, and an anti-inflammatory diet, with a recommendation to consult a doctor for a proper diagnosis.

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Learn

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learn Overview

learn Keratin

What role does keratin play in strengthening weak or thinning hair? Keratin strengthens hair by forming protective structures that prevent breakage and thinning.
Are keratin treatments good for people with alopecia, or do they only improve the hair’s appearance? Keratin treatments improve hair appearance but do not address alopecia or stimulate growth.
Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos mainly coats the hair rather than being absorbed.
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learn Hydrolyzed Keratin

learn Alpha Keratin

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