Keratin Expression by Corneal and Limbal Stem Cells During Development

August 2020 in “ Experimental eye research/Experimental Eye Research ”

Winston Whei‐Yang Kao

keratin limbal stem cells K5/K14 K8/K18 K8/K19 intermediate filaments K3/K12 corneal basal cells Meesmann's corneal dystrophy LSCs IF corneal dystrophy

Studysummary This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study reviewed the expression patterns of keratins in corneal and limbal stem cells during development, highlighting the role of keratins in providing structural support and stability to epithelial cells. It was found that limbal stem cells (LSCs) in humans express both K5/K14 or K8/K18 and K8/K19 intermediate filaments (IF), indicating the presence of two LSC populations. These cells can differentiate into limbal suprabasal cells expressing K3/K12 IF or migrate to become corneal basal cells co-expressing K3/K12 and K5/K14 before further differentiation. The study emphasized the importance of keratin expression in maintaining ocular surface tissue functions and noted that mutations in keratin genes can lead to pathologies such as Meesmann's corneal dystrophy.

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Research cited in this study

9 / 9 results

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