Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

    February 2012 in “ PloS one ”
    Xiaofeng Liang, Shreya Bhattacharya, Gaurav Bajaj, Gunjan Guha, Zhixing Wang, Jang Hyo-Sang, Mark Leid, Arup K. Indra, Gitali Ganguli‐Indra
    TLDR Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
    The study investigated the role of Ctip2 in cutaneous wound healing and hair follicle stem cell marker expression in mice lacking Ctip2 in the epidermis (Ctip2ep−/−). The results showed that these mice exhibited delayed wound healing, reduced keratinocyte migration, and aberrant expression of several hair follicle stem cell markers, including K15, NFATc1, CD34, and CD133. The findings suggested that Ctip2 played a crucial role in skin regeneration and hair follicle stem cell function, highlighting its importance in keratinocyte proliferation, migration, and signaling pathways during wound repair.
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