TLDR Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
The study investigated the role of Ctip2 in cutaneous wound healing and hair follicle stem cell marker expression in mice lacking Ctip2 in the epidermis (Ctip2ep−/−). The results showed that these mice exhibited delayed wound healing, reduced keratinocyte migration, and aberrant expression of several hair follicle stem cell markers, including K15, NFATc1, CD34, and CD133. The findings suggested that Ctip2 played a crucial role in skin regeneration and hair follicle stem cell function, highlighting its importance in keratinocyte proliferation, migration, and signaling pathways during wound repair.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
450 citations,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
49 citations,
August 2004 in “The FASEB Journal” Mice with human skin protein K8 had more skin problems and cancer.
210 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.
109 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
141 citations,
August 2017 in “Developmental Dynamics” The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.
January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
Chrysanthemum zawadskii extract may help treat hair loss by promoting hair growth and affecting growth factors.
10 citations,
June 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Scientists successfully grew new hair follicles in regenerated mouse skin using mouse and human cells.
