Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice

    August 2004 in “ The FASEB Journal ”
    Mercedes Casanova, Ana Bravo, Jesús Martínez-Palacio … José L. Jorcano
    Studysummary This study found that transgenic mice expressing human keratin K8 in the epidermis showed increased progression of skin lesions toward malignancy, suggesting a role for K8 in the development of invasive skin cancer.
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    Research cited in this study 5

    1. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998
    2. The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted Current Biology · 1998
    3. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    4. The Secret Life of the Hair Follicle Trends in genetics · 1992
    5. Growth of the Hair Physiological Reviews · 1954

    Related research 2

    1. Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice The FASEB Journal · 2004
    2. Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin Biochemistry and Cell Biology · 1995