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Research

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research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.

research Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

25 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that applying topical imiquimod during mid and late telogen in mice activates hair follicle stem cells and influences immune cell infiltration, promoting hair cycle entry independently of Wnt signaling.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment

25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that while VDR is crucial for maintaining hair follicles in mice, their degeneration may be linked to impaired cell migration during hair growth phases rather than stem cell loss.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

This study found that Activin B at 10 ng/mL may promote vibrissae follicle growth in mice by enhancing hair matrix cell proliferation and cell cycle progression via ERK signaling pathways.

Defining the Molecular Signature of the Hair Follicle Dermal Sheath and Its Functional Requirement for Hair Cycle Progression During Catagen

research 862 Defining the molecular signature of the hair follicle dermal sheath and its functional requirement for hair cycle progression during catagen

April 2017 in “Journal of Investigative Dermatology”

This study identified the dermal sheath as a key component of the hair follicle niche, essential for outer root sheath regression during the hair cycle, highlighting its importance in hair follicle support and regulation.

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Community Join

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community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 2 years ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community Should I avoid a testosterone cycle if I care a lot about keeping my hair?

in Treatment 5 upvotes 4 weeks ago

Avoid testosterone cycles if you care about hair preservation, as they can accelerate hair loss despite using finasteride. Consider alternatives like dutasteride for better protection against hair loss.

community Progressi in 9 mesi, da luglio 2025 a marzo 2026

in Progress Pictures 153 upvotes 5 months ago

The user shared their 9-month hair regrowth progress using topical Minoxidil 5%, finasteride 0.05%, retinoic acid 0.01%, dermastamping, ketoconazole shampoo, and supplements like biotin. They experienced some hair density improvement but minimal change in the hairline, with initial side effects from finasteride that resolved after dosage adjustment.

community Loosing ground, on fin and min. 4years progression

in Update 191 upvotes 1 year ago

The user has been using finasteride and minoxidil for hair loss since 2021, with some initial regrowth but now considering switching to dutasteride due to concerns about further hair loss. They also use microneedling and are exploring tretinoin, while others suggest adding oral minoxidil or a hair transplant for better results.

community Balding Sucks. Balding Young is Awful. Balding Young and being Unable to Grow any Facial Hair is Hell on Earth

in Update 339 upvotes 1 year ago

A 25-year-old is frustrated with hair loss and inability to grow facial hair despite using oral finasteride and minoxidil for over a year. Suggestions include trying topical treatments, considering a hair system, or seeking professional help for mental health.

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Learn

9 / 66 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Overview

learn sh-Polypeptide-7

learn Beta Polypeptide

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
When will I see new hair growth after a hair transplant? New hair growth usually starts 2-4 months after a hair transplant.

learn Cyproterone

How long does it take for cyproterone to work on hair loss? There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.

learn horsetail extract

How long should you use horsetail extract before noticing stronger or thicker hair? No published trial has tested horsetail extract for hair thinning, so no evidence-based timeline exists; the hair cycle means any supplement needs at least three months, and more realistically five to six, before a change could be visible at all.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

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Clinics

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All 43 clinic results →

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas