Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation

    August 1998 in “ The Journal of Cell Biology ”
    Rudolph D. Paladini, Pierre A. Coulombe
    Studysummary In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.
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    Research cited in this study 13

    1. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    2. Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice Journal of Biological Chemistry · 1997
    3. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    4. Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin Biochemistry and Cell Biology · 1995
    5. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    6. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    7. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991
    8. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    9. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984
    10. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle Journal of Investigative Dermatology · 1984
    11. Distribution and Number of Epidermal Growth Factor Receptors in Skin Is Related to Epithelial Cell Growth Developmental Biology · 1983
    12. Epidermal Growth Factor Delays Development of Epidermis and Hair Follicles in Mice During First Coat Growth The Anatomical Record · 1983
    13. Effects of Epidermal Growth Factor on Hair Growth in the Mouse Journal of Endocrinology · 1981

    Related research 2

    1. Analysis of Proliferation, Apoptosis, and Keratin Expression in Cultured Normal and Immortalized Human Buccal Keratinocytes European Journal Of Oral Sciences · 2003
    2. Keratin and Skin Disorders Cell biology international · 1996