Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice

    Kenzo Takahashi, Pierre A. Coulombe
    Studysummary This study found that regulatory sequences crucial for inducing K6a expression in response to epidermal injury are located in specific upstream regions of the K6a gene in transgenic mice.
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    Research cited in this study 7

    1. A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice Proceedings of the National Academy of Sciences · 1995
    2. Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair Follicle Derived Tumors Compared to Nonfollicular Epithelial Skin Tumors Journal of Investigative Dermatology · 1995
    3. Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin The Journal of Cell Biology · 1994
    4. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993
    5. Concerted Gene Duplications in the Two Keratin Gene Families Journal of Molecular Evolution · 1988
    6. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    7. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987

    Related research 1

    1. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989