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    Glossary Cortex

    middle layer of hair responsible for strength and color

    The cortex is the middle layer of a hair strand, located between the outer cuticle and the inner medulla. It is composed of long keratin filaments and is responsible for the hair's strength, color, and elasticity. The cortex contains melanin, which gives hair its color, and its structure can be altered by chemical treatments like coloring or perming.

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    1. Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats Frontiers in Behavioral Neuroscience · 2015 · 34 citations
    2. A highly resistant structure between cuticle and cortex of human hair International Journal of Cosmetic Science · 2016 · 10 citations
    3. A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier International Journal of Cosmetic Science · 2018 · 6 citations
    4. Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist Drug Research · 2011 · 5 citations
    5. Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro PubMed · 2019 · 4 citations
    6. A summary of in vitro, phase I, and phase II studies evaluating the mechanism of action, safety, and efficacy of clascoterone (cortexolone 17a propionate, CB-03-01) in androgenetic alopecia Journal of The American Academy of Dermatology · 2019 · 3 citations
    7. A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity Clinical Pharmacology in Drug Development · 2021 · 2 citations
    8. A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer ecancermedicalscience · 2017 · 1 citations
    9. Thermal Induced Changes in Cuticle and Cortex to Chemically Treated Hair Biopolymers · 2025
    10. Characterization of the mechanical properties of the cortex region of human hair fibers by multiparametric Atomic Force Microscopy mapping Ultramicroscopy · 2024
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    Community 2 of 8

    1. Which markers and nutrients could contribute to hair health in context of checking for deficiencies? Reddit · 1 Aug 2025
    2. where/how to buy Cb-03-01 for "research purposes"? Reddit · 1 Jan 2026
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