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Glossary Cortex

middle layer of hair responsible for strength and color

The cortex is the middle layer of a hair strand, located between the outer cuticle and the inner medulla. It is composed of long keratin filaments and is responsible for the hair's strength, color, and elasticity. The cortex contains melanin, which gives hair its color, and its structure can be altered by chemical treatments like coloring or perming.

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Research

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research Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats

34 citations , August 2015 in “Frontiers in Behavioral Neuroscience”

This study found that augmenting or reducing allopregnanolone activity in the BNST affected contextual fear expression in rats, suggesting sex differences in anxiety may be linked to neuroactive steroid regulation.

research A highly resistant structure between cuticle and cortex of human hair

10 citations , November 2016 in “International Journal of Cosmetic Science”

This study proposed the existence of a membrane-like structure between the cuticle and cortex in human hair, which may provide strong protection against external stimuli.

research A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier

6 citations , December 2018 in “International Journal of Cosmetic Science”

This study found that a highly resistant structure, located at the interface between the cuticle and cortex of human hair, acts as a penetration barrier, which the authors propose to name the "cuticle anchored resistant base" or CARB.

research Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist

5 citations , December 2011 in “Drug Research”

This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.

research Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro

4 citations , February 2019 in “PubMed”

This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.

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learn Hair Transplant

What is a graft in the context of hair transplants? A graft in hair transplants is a cluster of 1 to 4 hair follicles.

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community Which markers and nutrients could contribute to hair health in context of checking for deficiencies?

4 upvotes 1 year ago

Hair loss is primarily genetic, and nutrient deficiencies are unlikely to be the cause. DHT inhibitors can slow hair loss, but concerns about side effects are common.

community Any information on if adapalene also increases sulfotransferase the same way tretinoin does?

in Minoxidil 2 upvotes 9 months ago

The conversation discusses whether adapalene (Differin) increases sulfotransferase like tretinoin does, in the context of combining it with minoxidil for hair treatment. The responses indicate that adapalene does not have the same effect as tretinoin.

community Could male-pattern baldness have a secondary photobiological function? The Solar Window Hypothesis

11 upvotes 3 weeks ago

Male-pattern baldness might increase UVB exposure on the scalp, potentially affecting vitamin D and skeletal health. The hypothesis is debated, with some seeing it as a minor benefit in specific contexts.

community 6 weeks minoxidil… and spironolactone

33 upvotes 11 months ago

Minoxidil and spironolactone are used for hair regrowth, with visible progress noted. Spironolactone is discussed as a treatment option, particularly in the context of transitioning, with concerns about its effects on men.

community Please report or comment fact checks on these Instagram accounts

in Research/Science 13 upvotes 1 year ago

False information about hair loss is being spread, misleading people. Treatments like Minoxidil, finasteride, and RU58841 are not mentioned in the context of the misinformation.

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