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Glossary Prefrontal Cortex

region of the brain responsible for decision-making and social behavior

The prefrontal cortex (PFC) is the front part of the brain's frontal lobes, located just behind the forehead. It is crucial for complex cognitive behaviors such as decision-making, problem-solving, and controlling social behavior. The PFC is also involved in personality expression and moderating social conduct, making it essential for planning and executing tasks.

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research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

3 citations , January 2024 in “Frontiers in Endocrinology”

This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.

research Pregnancy's lasting imprint: Late pregnancy allopregnanolone alters rat fear recall and medial prefrontal cortex activity

January 2026 in “Hormones and Behavior”

In this study, researchers observed that reproductive experience in female rats altered fear memory and medial prefrontal cortex (mPFC) activity, with pregnant and parous rats showing impaired fear recall compared to nulliparous controls, highlighting the influence of pregnancy-related neurosteroids on cognitive function and brain activity.

research Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex

48 citations , May 2019 in “Genome Biology”

This study identified genetic, biological, and technical factors that influence circRNA expression in the human brain, connecting these factors to potential genetic risk for diseases like schizophrenia and type II diabetes.

research Prefrontal 5α-reductase 2 mediates male-specific acute stress response

5 citations , January 2025 in “Science Advances”

In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.

Dietary Glucoraphanin Prevents the Onset of Psychosis in Adult Offspring After Maternal Immune Activation

research Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation

36 citations , January 2018 in “Scientific reports”

This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.

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10 upvotes 3 weeks ago

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11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

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