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    Glossary Cortex

    middle layer of hair responsible for strength and color

    The cortex is the middle layer of a hair strand, located between the outer cuticle and the inner medulla. It is composed of long keratin filaments and is responsible for the hair's strength, color, and elasticity. The cortex contains melanin, which gives hair its color, and its structure can be altered by chemical treatments like coloring or perming.

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    1. Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats Frontiers in Behavioral Neuroscience · 2015 · 34 citations
    2. A highly resistant structure between cuticle and cortex of human hair International Journal of Cosmetic Science · 2016 · 10 citations
    3. A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier International Journal of Cosmetic Science · 2018 · 6 citations
    4. Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist Drug Research · 2011 · 5 citations
    5. Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro PubMed · 2019 · 4 citations
    6. A summary of in vitro, phase I, and phase II studies evaluating the mechanism of action, safety, and efficacy of clascoterone (cortexolone 17a propionate, CB-03-01) in androgenetic alopecia Journal of The American Academy of Dermatology · 2019 · 3 citations
    7. A Phase 1 Study to Investigate the Effects of Cortexolone 17α‐Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity Clinical Pharmacology in Drug Development · 2021 · 2 citations
    8. A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer ecancermedicalscience · 2017 · 1 citations
    9. Thermal Induced Changes in Cuticle and Cortex to Chemically Treated Hair Biopolymers · 2025
    10. Characterization of the mechanical properties of the cortex region of human hair fibers by multiparametric Atomic Force Microscopy mapping Ultramicroscopy · 2024
    11. Cortexolone 17a-propionate: A new antiandrogen acting on hair dermal papilla cells for the treatment of androgenic alopecia Journal of The American Academy of Dermatology · 2014
    12. Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen Journal of the American Academy of Dermatology · 2012
    13. Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer EBioMedicine · 2019 · 13 citations
    14. Contextualización histórica y social de la remoción del vello púbico femenino Revista Colombiana de Obstetricia y Ginecología · 2013 · 2 citations
    15. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development · 2000 · 109 citations
    16. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    17. Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra. Biological & Pharmaceutical Bulletin · 2001 · 51 citations
    18. Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase Scientific Reports · 2016 · 43 citations
    19. THE FUNCTIONAL INTERRELATIONSHIP OF THE ANTERIOR PITUITARY AND THE ADRENAL CORTEX Annals of Internal Medicine · 1951 · 41 citations
    20. hKAP1.6 and hKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins are Expressed in the Hair Follicle Cortex 2002 · 24 citations
    21. Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex PloS one · 2011 · 21 citations
    22. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge Experimental Dermatology · 2009 · 18 citations
    23. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations
    24. The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins Biological chemistry · 2002 · 13 citations
    25. [Cushing syndrome during pregnancy. New diagnostic methods used in 3 cases of adrenal cortex carcinoma]. PubMed · 1992 · 10 citations
    26. Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix Chinese Medical Journal · 2013 · 4 citations
    27. Adrenal Cortex Tumors and Hyperplasias InTech eBooks · 2011 · 2 citations
    28. Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes Bone and Joint Research · 2026
    29. El contexto de la tricología en el médico Acta Bioclínica · 2024 · 1 citations
    30. Alopecia androgenética: uma revisão sobre a resolutividade do tratamento cirúrgico e sua implicação no contexto biopsicossocial do paciente Brazilian Journal of Health Review · 2023