Defective Trophoblast Function in Mice With a Targeted Mutation of Ets2

The study investigated the role of the Ets2 gene in mice by creating a targeted mutation. Researchers found that mice with this mutation exhibited defective trophoblast function, which is crucial for placental development. This defect led to embryonic lethality, indicating the essential role of Ets2 in embryogenesis. The findings highlighted the importance of Ets2 in the regulation of genes necessary for trophoblast function and placental development.