Role of EZH2 in Uterine Gland Development

This study investigates the role of Enhancer of zeste homolog 2 (EZH2) in uterine gland development, crucial for pregnancy success. Using mice with conditional deletion of Ezh2 via Amhr2-Cre recombinase, researchers found significant defects in uterine adenogenesis, leading to impaired uterine function and pregnancy loss. Unlike previous models, these mice did not show differentiation of basal-like cells in the uterus. Transcriptomic profiling revealed dysregulation in genes linked to key developmental and disease pathways. The findings highlight an unrecognized role of EZH2 in postnatal uterine gland development, essential for female fertility.