Role of EZH2 in Uterine Gland Development

This study explores the role of EZH2 in uterine gland development using Ezh2 Amhr2-Cre conditional knockout mice, revealing significant defects in uterine adenogenesis and impaired uterine function, leading to pregnancy loss. The research identifies 212 differentially expressed genes, with notable changes in hedgehog and retinoic acid (RA) signaling pathways, which are crucial for uterine development. The study also notes a reduction in uterine natural killer cells and compromised decidual integrity, although some pregnancy events still occur, suggesting a threshold number of glands is necessary for pregnancy maintenance. These findings highlight the essential role of EZH2 in uterine gland development and its impact on female fertility.