TLDR Tsc2-deficient stem cells can help understand and treat TSC-related tumors.
The study established Tsc2-deficient embryonic stem cells (ESCs) from Eker rats, which maintained pluripotency and could differentiate into all three germ layers. Tsc2−/− ESCs showed abnormal mTORC1 pathway activation and distinct gene expression profiles compared to Tsc2+/+ and Tsc2+/- ESCs. These cells could form teratomas but caused embryonic lethality in chimeras. The research suggested that Tsc2 deficiency might lead to abnormal differentiation, potentially affecting hair development, and highlighted the use of these ESCs as models for studying Tsc2 mutation-related pathogenesis and identifying therapeutic targets.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
8 citations
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September 2013 in “Molecular carcinogenesis” Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.
42 citations
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February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
19 citations
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July 2018 in “Mechanisms of Ageing and Development” Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.
36 citations
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March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
161 citations
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August 2013 in “Journal of experimental botany” Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.
