Transcription Factor-Based Transdifferentiation of Human Embryonic to Trophoblast Stem Cells

    September 2024 in “ Development ”
    Paula A. Balestrini, Ahmed Abdelbaki, Afshan McCarthy … Norah M. E. Fogarty
    Studysummary This study investigated transcription factors in human trophectoderm cells during development, finding that GATA2 and GATA3 are essential for transforming stem cells into induced trophoblast stem cells, which display characteristics similar to placental progenitor cells, offering new methods for modeling placental-associated diseases.
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