ATP-Dependent Chromatin Remodeling During Mammalian Development

The document from August 15, 2016, reviews the critical roles of ATP-dependent chromatin-remodeling complexes in mammalian development, focusing on the BAF, ISWI, CHD, and INO80/SWR classes. These complexes are essential for gene expression regulation, cell differentiation, and organogenesis. BAF complexes, particularly the BAF complex, are involved in early embryonic development, neural development, and hair follicle and skin development. They interact with lineage-specific transcription factors to regulate gene transcription at specific genomic sites. ISWI complexes are implicated in maintaining open chromatin for early development and promoting closed chromatin for differentiation. CHD proteins are crucial for pre-implantation embryo development and maintaining embryonic stem cell pluripotency, with some linked to disorders like CHARGE syndrome and autism. INO80/SWR complexes are vital for ESC self-renewal, pluripotency, and differentiation, as well as muscle differentiation and embryonic hematopoiesis. The document underscores the importance of understanding these complexes' subunit composition and mechanisms to potentially develop therapeutic strategies for regeneration and treatment of developmental disorders.