Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine

    August 2024 in “ Heliyon ”
    Lingxi Wei, Wenqi Yan, Wahid Shah, Zhengwei Zhang, Minghe Wang, Biao Liu, Zhaoxia Xue, Yixin Cao, Xinyu Hou, Kai Zhang, Beibei Yan, Xiaogang Wang
    TLDR Stem cell transplantation shows promise for treating diseases but faces challenges like safety, ethics, and cost.
    The review highlights the potential of stem cell transplantation for regenerative medicine, focusing on various stem cell types like embryonic, induced pluripotent, and mesenchymal stem cells. These cells show promise in regenerating tissues such as bone, cartilage, neurological, and hematological tissues, and have applications in treating conditions like spinal cord injuries, cardiovascular diseases, and alopecia. However, challenges such as tumorigenicity, immune rejection, ethical concerns, and the need for standardized protocols persist. Innovations like NanoScript technology and GAG-coated dermal papillary cells enhance therapeutic potential, but overcoming scalability, ethical concerns, and high research costs is crucial. Collaboration among scientists, clinicians, and regulators is essential to balance scientific progress with ethical responsibility, aiming for transformative changes in disease treatment and improved quality of life.
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