The Promising Prospect of Human Hair Follicle Regeneration in the Shadow of New Tissue Engineering Strategies

The document discusses the challenges and potential solutions for hair follicle (HF) regeneration, a crucial aspect for treating alopecia. Current treatments for alopecia, such as hair growth stimulants, herbal products, and hair transplantation, have limitations, including severe side effects and the potential for recurrence of alopecia upon cessation of medication. The paper highlights the potential of regenerative medicine, specifically HF bioengineering, which aims to recreate the environment of early hair morphogenesis. However, the functional construction of HFs from isolated cells under certain culture conditions remains a challenge. Most studies are focusing on creating 3D structures that mimic the HF microenvironment and signaling pathways in vivo. The successful development of human HFs produced in vitro could have significant biological applications beyond curing hair loss, potentially replacing conventional methods in the beauty and medical industries.