Cellular Nanofiber Structure with Secretory Activity-Promoting Characteristics for Multicellular Spheroid Formation and Hair Follicle Regeneration

January 2020 in “ ACS Applied Materials & Interfaces ”

Kexin Zhang, Xiufeng Bai, Zhipeng Yuan, Xintao Cao, Xiangyu Jiao, Yan Qin, Yongqiang Wen, Xueji Zhang

cellular nanofiber structure hair follicle regeneration multicellular spheroid formation chitosan polyvinyl alcohol glutaraldehyde tissue engineering nanofiber sponge

Studysummary This study reported that a novel chitosan/polyvinyl alcohol nanofiber sponge effectively enhances the hair follicle-inducing ability of dermal papilla multicellular spheroids in a mouse model. Our plain-language summary of this paper — not a Tressless recommendation.

A study from 3 years ago developed a cellular nanofiber structure that promotes hair follicle regeneration and multicellular spheroid formation, with promising results for hair regeneration and tissue engineering. The structure had secretory activity-promoting properties and was successful in regenerating hair follicles in mice. The nanofiber sponge was made of chitosan and polyvinyl alcohol and was cross-linked with glutaraldehyde vapors to improve its stability. The study suggests that the cellular nanofiber structure has potential for promoting hair follicle regeneration.

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