Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

    January 2021 in “ Stem cell research & therapy
    Carla M. Abreu, Rogério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira, A. P. Marques
    TLDR Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.
    The study demonstrated that interfollicular epidermal stem-like keratinocytes (EpSlKCs) could effectively recreate hair follicle (HF) and sebaceous gland (SG)-like structures when combined with dermal papilla (DP) cells in mice. EpSlKCs, derived from discarded human skin, showed high proliferative capacity and maintained an undifferentiated state, crucial for hair regeneration. Co-culturing EpSlKCs with DP cells promoted mutual growth and differentiation, indicated by the balanced expression of VEGF and BMP2. Although the recreated structures did not produce a hair shaft, the findings suggested that EpSlKCs are a promising alternative to human hair follicular keratinocytes (HHFKCs) for HF epithelial compartment recreation, potentially advancing hair regeneration therapies.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 18 results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community does lowering your prolactin levels regrow hair?

      in Research/Science  10 upvotes 2 years ago
      The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

      community How dutasteride makes hair loss impossible

      in Chat  142 upvotes 1 month ago
      Dutasteride is discussed as a treatment that makes hair loss impossible, with some users sharing experiences of hair regrowth and side effects. Finasteride and oral minoxidil are also mentioned as treatments, with concerns about side effects and effectiveness.

    Related Research

    4 / 4 results