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    Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

    December 2017 in “ International Journal of Dermatology ”
    Rodney Sinclair
    Studysummary This study reported that once-daily treatment with oral minoxidil and spironolactone for 12 months reduced hair loss severity and hair shedding in women with pattern hair loss, with generally mild side effects, though results came from an uncontrolled, observational pilot study.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 27

    1. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    2. Destruction of the Arrector Pili Muscle and Fat Infiltration in Androgenic Alopecia British Journal of Dermatology · 2014
    3. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    4. Winding the Clock Back on Female Androgenetic Alopecia British Journal of Dermatology · 2012
    5. Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss British Journal of Dermatology · 2012
    6. Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss British Journal of Dermatology · 2011
    7. Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia British Journal of Dermatology · 2011
    8. Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide Australasian Journal of Dermatology · 2011
    9. Quality of Life in Australian Women with Female Pattern Hair Loss The Open Dermatology Journal · 2010
    10. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010
    11. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    12. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008
    13. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    14. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    15. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    16. The Lack of Significant Changes in Scalp Hair Follicle Density With Advancing Age British Journal of Dermatology · 2005
    17. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    18. Chronic Telogen Effluvium: A Study of 5 Patients Over 7 Years Journal of The American Academy of Dermatology · 2005
    19. The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women Journal of The American Academy of Dermatology · 2004
    20. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    21. Finasteride for Female Androgenetic Alopecia British Journal of Dermatology · 2002
    22. Spironolactone-Induced Hepatitis Australasian journal of dermatology · 2001
    23. The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 1999
    24. Androgenetic Alopecia in the Female Archives of Dermatology · 1994
    25. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993
    26. Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    27. Reversal of Baldness in Patient Receiving Minoxidil for Hypertension The New England Journal of Medicine · 1980

    Related research 10

    1. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    2. Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil JAAD case reports · 2022
    3. Efficacy and Safety Profile of Oral Spironolactone Use for Androgenic Alopecia: A Systematic Review PubMed · 2021
    4. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    5. Spironolactone for Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    6. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    7. Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide Australasian Journal of Dermatology · 2011
    8. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    9. Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women International Journal of Dermatology · 1993
    10. Treatment of Female Androgenetic Alopecia with Minoxidil 2% International Journal of Dermatology · 1992