TLDR Spironolactone effectively treats female pattern hair loss with few side effects.
This document is a letter discussing a retrospective observational study evaluating the efficacy and side-effect profile of spironolactone as combination or mono-therapy in female pattern hair loss (FPHL). Data from adult women with FPHL, prescribed spironolactone between March 2015 and March 2019, were retrospectively analyzed. The average spironolactone dose was 100 mg daily (range 25 to 200 mg daily) for a minimum of 6 months. Overall, 87% of patients were on spironolactone monotherapy or added spironolactone to a long-term hair loss treatment regimen. The study found that spironolactone, either as mono- or adjunct therapy, is an effective and well-tolerated option for FPHL.
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80 citations
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January 2018 in “International Journal of Dermatology” Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.
26 citations
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October 2015 in “Journal of The American Academy of Dermatology” Spironolactone may effectively treat female hair loss, especially with hyperandrogenism signs.
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April 2006 in “Expert Review of Dermatology” Antiandrogen therapy helps treat genetic hair loss.
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March 2005 in “British Journal of Dermatology” Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.
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October 2022 in “PubMed” Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.
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June 2021 in “Journal of Cosmetic Dermatology” Using minoxidil and tofacitinib together can effectively treat severe hair loss.
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July 2020 in “Journal of The American Academy of Dermatology” Spironolactone effectively treats female pattern hair loss with few side effects.
April 2019 in “Zagazig university medical journal” 80 citations
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January 2018 in “International Journal of Dermatology” Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.
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January 2015 in “Skin appendage disorders” Minoxidil treatment for hair loss can cause scalp allergy and severe hair loss.
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May 2011 in “Australasian Journal of Dermatology” Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.
21 citations
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February 2007 in “Australasian Journal of Dermatology” Spironolactone and minoxidil together effectively treat female pattern hair loss.