Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss

    May 2010 in “ PubMed
    Deepani Rathnayake, Rodney Sinclair
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    TLDR Spironolactone helps regrow hair in women with hair loss.
    The document discusses the use of spironolactone as an antiandrogen in the treatment of female pattern hair loss (FPHL). FPHL is a common cause of hair loss in women, and spironolactone has been shown to be effective in treating FPHL by blocking androgen receptors and reducing the production of androgens. The standard dose used is 100 to 200 mg daily, and lower doses of 50 to 75 mg have also been shown to stabilize hair loss in some women. A study investigated 80 women with biopsy-proven FPHL, and 44% of women had clearly visible hair regrowth after 12 months of spironolactone therapy. However, further work is required to establish the precise utility of spironolactone in FPHL and to determine the optimal dose.
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