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    Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss

    May 2010 in “ PubMed ”
    Deepani Rathnayake, Rodney Sinclair
    Studysummary This paper discusses spironolactone as a potential off-label treatment for female pattern hair loss, noting its ability to halt hair loss progression and induce partial regrowth in a significant number of women but reports no new clinical results.
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    Research cited in this study 37

    1. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    2. Successful Treatment of Female-Pattern Hair Loss with Spironolactone in a 9-Year-Old Girl Australasian Journal of Dermatology · 2009
    3. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008
    4. Hair Loss in Women The New England Journal of Medicine · 2007
    5. Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil Australasian Journal of Dermatology · 2007
    6. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    7. Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Journal of Investigative Dermatology Symposium Proceedings · 2005
    8. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    9. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    10. The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women Journal of The American Academy of Dermatology · 2004
    11. Women Who Present With Female Pattern Hair Loss Tend To Underestimate The Severity Of Their Hair Loss British Journal of Dermatology · 2004
    12. A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    13. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    14. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    15. Use of Cyproterone Acetate, Finasteride, and Spironolactone to Treat Idiopathic Hirsutism Fertility and Sterility · 2003
    16. Perception of Men with Androgenetic Alopecia by Women and Nonbalding Men in Korea: How the Nonbald Regard the Bald International Journal of Dermatology · 2002
    17. Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    18. Spironolactone-Induced Hepatitis Australasian journal of dermatology · 2001
    19. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    20. The Psychology of Hair Loss and Its Implications for Patient Care Clinics in Dermatology · 2001
    21. Androgenetic Alopecia in Men and Women Clinics in Dermatology · 2001
    22. Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss British Journal of Dermatology · 2001
    23. Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia) Dermatologic Surgery · 2001
    24. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    25. Diffuse Female Hair Loss: Are Androgens Necessary? British Journal of Dermatology · 1999
    26. The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 1999
    27. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    28. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    29. Antiandrogen Therapy in Dermatology International Journal of Dermatology · 1996
    30. Androgenetic Alopecia in the Female: Treatment with 2% Topical Minoxidil Solution Archives of Dermatology · 1994
    31. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993
    32. Psychological Characteristics of Women with Androgenetic Alopecia: A Controlled Study British Journal of Dermatology · 1991
    33. Natural Progression of Male Pattern Baldness in Young Men Clinical and Experimental Dermatology · 1991
    34. Patterned Androgenic Alopecia in Women Journal of The American Academy of Dermatology · 1988
    35. The Inheritance Of Common Baldness: To Be Or Not To Be? Journal of the American Academy of Dermatology · 1984
    36. Spironolactone Therapy for Hirsutism in a Hyperandrogenic Woman Annals of internal medicine · 1978
    37. Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex British Journal of Dermatology · 1977

    Related research 4

    1. Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide Australasian Journal of Dermatology · 2011
    2. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010
    3. The Evaluation and Management of Hirsutism Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology · 2003
    4. Anti-Androgens for the Treatment of Hirsutism Expert opinion on investigational drugs · 2002