Functional Hair Follicle Regeneration

January 2017 in “ Springer eBooks ”

Koh-ei Toyoshima, Takashi Tsuji

hair follicle regeneration hair loss treatment intracutaneous transplantation bioengineered hair follicle germ hair follicle-derived stem cells organ germ method organ regenerative therapy alopecia hair follicle regenerative medicine hair regeneration hair loss stem cell therapy hair transplant hair regrowth

Studysummary This review discusses recent advancements in hair follicle regeneration technologies, including the authors' own development of functional hair regeneration through bioengineered follicle germ transplantation, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This document discusses the potential for hair follicle regeneration therapy and the challenges of hair loss treatment. The authors successfully developed fully functional hair regeneration via intracutaneous transplantation of a bioengineered hair follicle germ, which was reconstituted from adult hair follicle-derived stem cells using their developed organ germ method. The paper concludes by discussing the potential of organ regenerative therapy for the medical cure of alopecia. The study provides evidence for the regeneration of a fully functional human hair follicle using bioengineering, which is applicable to human-derived cells and contributes to future developments in hair follicle regenerative medicine.

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Research cited in this study

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research Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ

6 citations , January 2016 in “Methods in molecular biology”

This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.

research Female Pattern Hair Loss: A Clinical and Pathophysiological Review

91 citations , August 2015 in “Anais Brasileiros De Dermatologia”

This review discusses the clinical, epidemiological, and pathophysiological aspects of female pattern hair loss, reporting no new research findings.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.

research An Overview of Alopecias

53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.

research Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation

66 citations , May 2012 in “Scientific Reports”

This study demonstrated that bioengineered hair follicles reconstituted from embryonic skin cells and transplanted into hosts can restore physiological hair functions, suggesting potential applications for treating alopecia.

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , July 2011 in “Stem Cells and Development”

This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.

research The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche

294 citations , February 2011 in “Cell”

Nephronectin helps attach muscle cells to hair follicles.

research Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis

338 citations , July 2009 in “Development”

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice

427 citations , April 2008 in “Nature Protocols”

research Defining Hair Follicles in the Age of Stem Cell Bioengineering

49 citations , September 2007 in “Journal of Investigative Dermatology”

The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

96 citations , April 2007 in “Journal of Investigative Dermatology”

In this study, co-grafting human keratinocytes with murine dermal papilla-enriched cells produced hair follicle-like structures, but without regular hair formation, suggesting anomalous folliculogenesis.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Bioengineering the Hair Follicle

26 citations , January 2007 in “Organogenesis”

This review outlines the evolution of hair follicle engineering and its foundational discoveries, but reports no new experimental results.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.

research Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control

127 citations , December 2005 in “Experimental Dermatology”

This study provides evidence that psychoemotional stress inhibits hair growth in mice by affecting the brain-hair follicle axis, with specific neuropeptides and treatments modulating this effect.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations , April 2005 in “Journal of Investigative Dermatology”

This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.

research Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages

268 citations , December 2003 in “Experimental Dermatology”

This study demonstrated that clonal dermal papilla and dermal sheath cell lines from hair follicles can differentiate into lipid and bone cells, suggesting their potential as a stem cell source for tissue engineering.

research Hair Follicle Stem Cells: Insights from the 2003 Workshop

142 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Changing Patterns of Localization of Putative Stem Cells in Developing Human Hair Follicles

87 citations , February 2000 in “Journal of Investigative Dermatology”

Stem cells in developing hair follicles move to specific areas as they mature.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

61 citations , October 1996 in “Development”

This study found that combining adult germinative epidermal cells with non-inductive dermal cells can stimulate hair follicle neogenesis, effectively altering the cells' status to enhance induction.

research Ability to Culture Dermal Papilla Cells from Red Deer Hair Follicles with Differing Hormonal Responses In Vivo Offers a New Model for Studying the Control of Hair Follicle Biology

16 citations , August 1996 in “The journal of experimental zoology/Journal of experimental zoology”

This study suggests that red deer stags provide a novel model for investigating hormonal regulation of hair growth due to the different cell growth rates in hair follicles during breeding and nonbreeding seasons.

research Hormones and Hair Growth: Variations in Androgen Receptor Content of Dermal Papilla Cells Cultured from Human and Red Deer Hair Follicles

34 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that androgens influence hair follicle behavior via the dermal papilla, using evidence from human and red deer cells with differing androgen responses as models.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.