Hox in Hair Growth and Development
April 2003
in “
Die Naturwissenschaften
”
Research cited in this study
20 / 20 resultsresearch Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation
In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.
research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression
This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.
research Molecular Mechanisms Regulating Hair Follicle Development
This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables
This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.
research P53 Involvement in the Control of Murine Hair Follicle Regression
This study found that p53 plays a crucial role in regulating apoptosis during hair follicle regression (catagen) in mice, and its absence leads to delayed progression and altered expression of apoptosis-related markers.
research Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia
This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.
research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle
Inhibiting Bmp signaling disrupts hair growth and differentiation.
research Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype
This study suggests that the structural integrity and physical proximity of Whn's DNA binding and activation domains are crucial for hair keratin gene activation and may explain the nude phenotype.
research Msx2 Deficiency in Mice Causes Pleiotropic Defects in Bone Growth and Ectodermal Organ Formation
This study found that Msx2-deficient mice exhibit skull and bone formation defects similar to those seen in human MSX2-related conditions, highlighting the gene's importance in skeletal and organ development.
research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation
This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.
research Splitting Hairs: Molecular Mechanisms of Hair and Feather Development
β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.
research Hoxc13 Mutant Mice Lack External Hair
This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.
research Transforming Growth Factor-β Receptor Type I and Type II Expression During Murine Hair Follicle Development and Cycling
TGF-β receptors are crucial for hair follicle development.
research Mutations in the Hair Cortex Keratin HHB6 Cause the Inherited Hair Disease Monilethrix
research The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair
This article integrates existing literature on hair follicle structure and formation at the cellular and molecular level, reporting no new findings.
research The Secret Life of the Hair Follicle
This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
research Androgens and the Hair Follicle: Cultured Human Dermal Papilla Cells as a Model System
research Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene
Mice with extra sheep genes had hair that fell out and regrew in cycles.
research Growth of the Hair
Hair growth is cyclic and influenced mainly by local factors.
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research Hox in the Niche Controls Hairy-geneity
This study shows that differences in Hoxc gene expression in hair follicle mesenchyme along the body axis contribute to regional variations in mammalian hair growth.
research Hoxc13 and the development of hair follicle
This review summarizes the role of Hoxc13 in regulating hair follicle development and growth, noting its influence on keratin and keratin-associated proteins, and reports no new experimental findings.
research Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration
This study found that Hoxc gene expression can reprogram mesenchymal dermal papilla cells, enhance epithelial stem cell regenerative potential, and promote region-specific hair follicle regeneration through Wnt signaling.
research Hox genes in development and beyond
This review provides an overview of Hox genes, focusing on their evolutionary history, genomic organization, and roles in development, but reports no new study results.
research Hox demarcates regional regeneration of adult hair follicle stem cells
Hox genes control hair follicle stem cell regeneration in different body regions.