Characterization of Human Keratin-Associated Protein 1 Family Members

    June 2003 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Yutaka Shimomura, Noriaki Aoki, Michael A. Rogers, Lutz Langbein, Jürgen Schweizer, Masaaki Ito
    TLDR Mutations in hKAP1 genes may cause hereditary hair disorders.
    The study characterized the human keratin-associated protein 1 (hKAP1) family, identifying eight hKAP1 genes with unique pentapeptide repeat structures in the repetitive I domain, which likely defined their functional characteristics. These genes were thought to have arisen through gene duplication and mutations. Expression studies showed that hKAP1 mRNAs were predominantly expressed in the cortical layer of human scalp hair. The research suggested that mutations in hKAP genes could be linked to hereditary hair disorders, similar to known mutations in hair keratin genes causing monilethrix. The findings emphasized the importance of further analysis of hKAP genes to understand hair characteristics and disorders.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 104 results

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 9 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Comprehensive Microneedling Guide

      in Microneedling  290 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  13 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Female Hair Loss, Is there anything else I should be doing?

       11 upvotes 10 years ago
      A 20-year old female experiencing hair loss, who has had normal blood tests and is currently using minoxidil as recommended by her doctor. She is asking if there are any other treatments she should consider.

      community Keratin fibers vs. Gossypium Herbaceum Hair fibers

      in Product  1 upvotes 3 months ago
      The conversation is about comparing keratin hair fibers to Gossypium Herbaceum hair fibers for diffuse hair loss. The user prefers keratin fibers for their durability and is seeking a bulk purchase option.

    Similar Research

    5 / 1000+ results