p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

    December 2015 in “ Journal of Investigative Dermatology ”
    Chunyan Liao, Guojiang Xie, Liyan Zhu … Zhicao Yue
    Studysummary This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases? BioEssays · 2014
    2. The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia Current opinion in cell biology · 2012
    3. Homozygous Dominant Missense Mutation in Keratin 17 Leads to Alopecia in Addition to Severe Pachyonychia Congenita Journal of Investigative Dermatology · 2012
    4. Keratin Disorders: From Gene to Therapy Human molecular genetics online/Human molecular genetics · 2011
    5. Characterization and Quantification of Wound-Induced Hair Follicle Neogenesis Using In Vivo Confocal Scanning Laser Microscopy Skin Research and Technology · 2011
    6. Endocrine Controls of Keratin Expression BioEssays · 2009
    7. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    8. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    9. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004
    10. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    11. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and Its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000
    12. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    13. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997