Molecular Pathology of Skin Adnexal Tumors

July 2021 in “ Histopathology ”

Jaclyn M. Plotzke, David J. Adams, Paul W. Harms

cutaneous adnexal tumors Ras/MAPK pathway PI3K pathway YAP/TAZ pathway beta-catenin pathway NF-κB pathway NUT marker poroma porocarcinoma PLAG1 marker mixed tumors

TLDR New markers and pathways have been found in skin tumors, helping better understand and diagnose them.

Recent research has identified diverse oncogenic drivers and tumor suppressor alterations in cutaneous adnexal tumors, implicating pathways such as Ras/MAPK, PI3K, YAP/TAZ, beta-catenin, and NF-κB. These findings have led to the identification of novel markers like NUT for poroma and porocarcinoma and PLAG1 for mixed tumors. This review provides a comprehensive update on the molecular pathology of these tumors, which can arise from structures in normal skin and may indicate inherited tumor syndromes.

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