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GlossaryPI3K/AKT pathway

regulates cell growth, survival, and metabolism

The PI3K/AKT pathway is a critical cell signaling pathway that helps regulate various cellular processes, including growth, survival, and metabolism. When activated, it can promote cell proliferation and inhibit programmed cell death (apoptosis), making it significant in contexts like cancer research and treatment, as well as in understanding hair growth and conditions like alopecia.

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research Inhibition of CISD1 Attenuates Cisplatin-Induced Hearing Loss in Mice via the PI3K and MAPK Pathways

May 2024 in “Biochemical pharmacology”

Blocking CISD1 reduces hearing loss from cisplatin in mice.

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations, April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations, June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations, November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons

11 citations, December 2011 in “Biochemical journal”

Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.

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community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.