Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway

June 2025 in “ Stem Cell Research & Therapy ”

Jiarui Zhang, Jinxing Peng, Zhexiang Fan, Hailin Wang, Lihong Wen, Yong Miao, Yu Chai, Zhiqi Hu, Ruosi Chen

isoproterenol androgenetic alopecia hair follicle stem cells PI3K/AKT/β-Catenin signaling pathway hair follicle miniaturization adrenergic signaling ISO AGA HFSCs

TLDR Isoproterenol may help treat hair loss by activating hair follicle stem cells.

The study investigates the therapeutic potential of isoproterenol (ISO) in treating androgenetic alopecia (AGA) by activating hair follicle stem cells (HFSCs) through the PI3K/AKT/β-Catenin signaling pathway. Involving 68 male participants with AGA, the research found that ISO treatment facilitated HFSC activation and proliferation, potentially reversing hair follicle miniaturization. Both animal models and AGA patients showed significant improvements in hair growth, with ISO promoting HFSC proliferation and differentiation. The study suggests that adrenergic signaling stimulation via ISO could be a promising strategy for managing hair loss, although further investigation into its long-term safety is needed.

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