Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway

    June 2025 in “ Stem Cell Research & Therapy ”
    Jiarui Zhang, Jinxing Peng, Zhexiang Fan … Ruosi Chen
    Studysummary In this study, researchers found that isoproterenol, an adrenergic β2 receptor agonist, promoted hair growth and hair follicle stem cell proliferation in models of androgenetic alopecia by modulating the PI3K/AKT/β-Catenin pathway, suggesting a potential new therapeutic strategy for hair loss.
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    Research cited in this study 20

    1. BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway International Journal of Molecular Sciences · 2023
    2. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    3. Pyridoxine Regulates Hair Follicle Development via the PI3K/Akt, Wnt, and Notch Signalling Pathways in Rex Rabbits Animal nutrition · 2021
    4. Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation Journal of Investigative Dermatology · 2021
    5. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021
    6. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    7. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    8. Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
    9. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    10. External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway Proceedings of the National Academy of Sciences of the United States of America · 2018
    11. Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version Journal of Dermatology · 2018
    12. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    13. Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles Cells tissues organs · 2016
    14. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    15. Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014
    16. Neonatal Murine Skin-Derived Cells Transplanted Using a Mini-Chamber Model Produce Robust and Normal Hair Journal of Tissue Engineering and Regenerative Medicine · 2013
    17. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    18. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010
    19. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    20. Neural Mechanisms of Hair Growth Control Journal of Investigative Dermatology Symposium Proceedings · 1997

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