BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway

July 2023 in “ International Journal of Molecular Sciences ”

Salvador Pérez-Mora, Juan Ocampo-López, María del Consuelo Gómez-García, David Guillermo Pérez-Ishiwara

BFNB Bacopa procumbens hair growth C57BL/6 mice pigmentation follicular cycle follicles hair length hair diameter EGF FGF7 PI3K-AKT-β-catenin pathway hair regeneration Bacopa epidermal growth factor fibroblast growth factor 7 PI3K-AKT-beta-catenin pathway

TLDR BFNB could be a promising treatment for hair growth.

The study investigated the effects of BFNB, a formulation derived from Bacopa procumbens, on hair growth in C57BL/6 mice. The results showed that BFNB significantly increased pigmentation and hair growth, accelerated the follicular cycle phases, and increased the number of follicles, hair length, and diameter. This was achieved by enhancing the expression of growth factors EGF and FGF7, and activating the PI3K-AKT-β-catenin signaling pathway, which are crucial for hair regeneration. The study concluded that BFNB could be a promising therapeutic alternative for stimulating hair growth.

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