Anxa1 Affects Murine Hair Follicle Growth Through Egf Signaling Pathway

December 2020 in “ Gene ”

Hao Zhang, Xiaoqiao Fu, Yue Ao, Miaomiao Nan, Ziyu Qiu, Xiuzhi Jia, Ying Xiao, Dongjun Liu, Xudong Guo

Annexin A1 ANXA1 hair follicle epidermal growth factor EGF hair follicle stem cell HFSC Notch1 Mkk7 phosphorylated AKT1 ERK/2

Studysummary This study found that ANXA1 may influence hair growth in mice by regulating hair follicle stem cell proliferation through the EGF signaling pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the role of Annexin A1 (ANXA1) in hair follicle (HF) development and hair growth in mice, focusing on its interaction with the epidermal growth factor (EGF) signaling pathway. Researchers used Anxa1 knock-out (KO) and over-expression (OE) mice models to explore its function. Results indicated that ANXA1 influenced hair growth by affecting HF density, diameter, and hair follicle stem cell (HFSC) proliferation. Molecular analysis revealed that ANXA1 expression was negatively correlated with EGF, Notch1, Mkk7, and phosphorylated AKT1 and ERK/2 proteins. These findings suggested that ANXA1 could regulate hair growth through the EGF signaling pathway, potentially working synergistically with the Notch1 pathway.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations , December 2018 in “IOP conference series. Materials science and engineering”

This study confirms that human CD34+ melanocyte stem cells can be differentiated into melanin-producing cells, suggesting potential for cellular therapy in treating skin degenerative diseases.

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

214 citations , April 2017 in “Cell”

This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.

research Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

36 citations , April 2016 in “Biochimie”

This study shows that the concentration of epidermal growth factor (EGF) is crucial for determining whether mink hair follicles are promoted or inhibited in vitro, with involvement of the Notch signaling pathway in DP cell proliferation.

research Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses

10 citations , January 2016 in “PLOS ONE”

This study investigated protein expression changes during mouse hair follicle cycles and suggested their involvement in biological networks, potentially identifying targets for hair disease therapy.

research Role of Arachidonic Acid in Promoting Hair Growth

29 citations , January 2016 in “Annals of dermatology/Annals of Dermatology”

This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.

Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway

research Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway

27 citations , August 2015 in “Experimental Dermatology”

In this study, electrical stimuli at low voltage and frequency settings promoted hair growth in vitro and in rabbit models, possibly by activating pathways like Wnt/β-catenin.

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

19 citations , May 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that mice lacking the type 3 IP(3) receptor in their hair follicles experienced repetitive hair loss and regrowth, indicating disrupted hair-cycle regulation potentially linked to specific signaling pathways.

research Compartmentalized Organization: A Common and Required Feature of Stem Cell Niches?

63 citations , April 2010 in “Development”

This article discusses the bi-compartmental organization of hair follicle stem cell niches for balancing stem cell cycling and organ growth and proposes similar structures may exist in other adult stem cell niches but reports no new experimental results.

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations , May 2009 in “Development”

This study found that downregulation of EGF and KGF signaling is necessary for hair follicle initiation in placodes, revealing a new role for KGF in hair follicle formation in mice.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations , April 2009 in “Journal of Investigative Dermatology”

This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control

158 citations , May 2003 in “Journal of Investigative Dermatology”

This study observed that hair follicle mesenchyme in mice exhibits significant plasticity during the hair cycle, with cell migration and changes in papilla size impacting hair production.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations , September 2001 in “Journal of The American Academy of Dermatology”

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.