Anxa1 Affects Murine Hair Follicle Growth Through Egf Signaling Pathway

The study investigated the role of Annexin A1 (ANXA1) in hair follicle (HF) development and hair growth in mice, focusing on its interaction with the epidermal growth factor (EGF) signaling pathway. Researchers used Anxa1 knock-out (KO) and over-expression (OE) mice models to explore its function. Results indicated that ANXA1 influenced hair growth by affecting HF density, diameter, and hair follicle stem cell (HFSC) proliferation. Molecular analysis revealed that ANXA1 expression was negatively correlated with EGF, Notch1, Mkk7, and phosphorylated AKT1 and ERK/2 proteins. These findings suggested that ANXA1 could regulate hair growth through the EGF signaling pathway, potentially working synergistically with the Notch1 pathway.