Single-Cell Transcriptomics Defines Keratinocyte Differentiation in Avian Scutate Scales

    January 2022 in “ Scientific reports ”
    Julia Lachner, Florian Ehrlich, Matthias Wielscher … Leopold Eckhart
    Studysummary This study identified distinct gene expression programs in keratinocytes responsible for forming hard scales and soft interscale epidermis in chickens, revealing conserved differentiation genes similar to those in human skin.
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    Research cited in this study 8

    1. Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates Molecular biology and evolution · 2019
    2. Review: Evolution And Diversification Of Corneous Beta-Proteins, The Characteristic Epidermal Proteins Of Reptiles And Birds Journal of Experimental Zoology Part B Molecular and Developmental Evolution · 2018
    3. Comprehensive Molecular and Cellular Studies Suggest Avian Scutate Scales Are Secondarily Derived from Feathers, and More Distant from Reptilian Scales Scientific Reports · 2018
    4. Transcriptome Analyses of Reprogrammed Feather/Scale Chimeric Explants Revealed Co-Expressed Epithelial Gene Networks During Organ Specification BMC genomics · 2018
    5. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014
    6. Reptile Scale Paradigm: Evo-Devo, Pattern Formation and Regeneration The International Journal of Developmental Biology · 2009
    7. Identification of Reptilian Genes Encoding Hair Keratin-Like Proteins Suggests a New Scenario for the Evolutionary Origin of Hair Proceedings of the National Academy of Sciences · 2008
    8. Scratching the Surface of Skin Development Nature · 2007

    Related research 1

    1. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989