TLDR Key genes can rewire networks, changing skin appendage types.
The study explored the molecular mechanisms behind skin appendage phenotypes, focusing on feather and scale primordium genes. Using recombination experiments and systems biology, researchers found that dermal fate remained stable while epidermal fate was reprogrammed. Transcriptome analyses revealed a regulatory gene network, organized around β-catenin and retinoic acid (RA), which influenced skin appendage types. ATAC sequencing identified about 1000 altered chromatin open sites. The study concluded that these gene networks are highly interconnected, and perturbing key genes can rewire the network, leading to changes in appendage phenotypes, similar to endogenous tissue reprogramming.
19 citations
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April 2015 in “Developmental Dynamics” The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
151 citations
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November 2014 in “Annual Review of Animal Biosciences” Feathers are crucial for understanding bird evolution, development, and have inspired biomimetic research.
26 citations
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December 2013 in “Seminars in cell & developmental biology” Skin varies in thickness, color, and features due to complex genetic and cellular processes.
21 citations
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June 2016 in “Genesis” Researchers identified specific genes that are important for mouse skin cell development and healing.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Ezh2 controls skin development by balancing signals for dermal and epidermal growth.
6 citations
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June 2021 in “Developmental biology” Dermal EZH2 controls skin cell development and hair growth in mice.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Dermal EZH2 controls skin cell growth and differentiation in mice.
3 citations
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March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
