Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development
November 2020
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
EZH2 Wnt/β-catenin signaling retinoic acid signaling dermal differentiation epidermal proliferation Polycomb Repressive Complex 2 PRC2 dermal fibroblast progenitors epidermal keratinocytes hair follicle initiation epidermal hyperplasia RA signaling Wnt signaling retinoic acid skin development hair growth skin cells
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This study found that the Polycomb Repressive Complex 2, particularly its component Ezh2, is crucial in regulating dermal fibroblast differentiation and epidermal keratinocyte proliferation during murine skin development.
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