Epidermal Wnt/Beta-Catenin Signaling Promotes Dermal Adipocyte Differentiation During Hair Follicle Morphogenesis and Regeneration
December 2012
in “
Journal of Dermatological Science
”
Wnt/beta-catenin signaling FGF18 signaling hair cycle phases human induced pluripotent stem cell WNT signaling pathway hair follicle regeneration BNIP3 epidermal keratinocytes dermal adipocyte differentiation hair follicle development hair follicle repair Runx1 Runx3 keratinocyte differentiation keratinocyte proliferation alopecia areata chemokine CXCL10 Th1/Tc1 cell infiltration Tc1 cell accumulation estrogen VEGF expression dermal papilla cells female pattern hair loss Wnt signaling FGF18 hair cycle iPSC WNT pathway hair regeneration keratinocytes adipocyte differentiation hair development hair repair keratinocyte keratinocyte growth CXCL10 Th1/Tc1 cells Tc1 cells VEGF dermal papilla female hair loss
Studysummary This study found that activating Wnt/beta-catenin signaling in hair follicles is sufficient to induce adipocyte generation in the dermis, affecting both hair follicle stem cell activation and adipocyte differentiation.
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