Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages

    May 2025 in “ Journal of Developmental Biology ”
    Attila Placido Sachslehner, David Parry, Leopold Eckhart
    Studysummary This study reports that KRTAP-like proteins, which resemble keratin-associated proteins found in mammals, are also present in the cornified teeth of various lamprey species, suggesting these proteins may serve similar functions in skin appendages across different vertebrates despite independent evolutionary origins.
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    Research cited in this study 23

    1. Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair, and Other Cornified Epithelial Structures Animals · 2025
    2. Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-Option in the Evolution of the Hair Follicle BMC ecology and evolution · 2023
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    4. The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes International journal of molecular sciences · 2021
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    6. Macrofibril Formation Advances in experimental medicine and biology · 2018
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    8. Trichocyte Keratin-Associated Proteins Advances in experimental medicine and biology · 2018
    9. Diversity of Trichocyte Keratins and Keratin-Associated Proteins Advances in experimental medicine and biology · 2018
    10. Evolution of Trichocyte Keratins Advances in experimental medicine and biology · 2018
    11. Wool Keratin-Associated Protein Genes in Sheep: A Review Genes · 2016
    12. Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments BMC genomics · 2014
    13. Krtap11-1, A Hair Keratin-Associated Protein, As A Possible Crucial Element For The Physical Properties Of Hair Shafts Journal of Dermatological Science · 2014
    14. Bidirectional Binding Property of High Glycine–Tyrosine Keratin-Associated Protein Contributes to the Mechanical Strength and Shape of Hair Journal of structural biology · 2013
    15. Characterization of the Human Hair Keratin-Associated Protein 2 (KRTAP2) Gene Family Journal of Investigative Dermatology · 2012
    16. An Updated Nomenclature for Keratin-Associated Proteins International Journal of Biological Sciences · 2012
    17. Identification of the C-Terminal Tail Domain of AHF/Trichohyalin as the Critical Site for Modulation of the Keratin Filamentous Meshwork in the Keratinocyte Journal of Dermatological Science · 2011
    18. Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair Journal of Investigative Dermatology · 2009
    19. Molecular Evolution of the Keratin Associated Protein Gene Family in Mammals: Role in the Evolution of Mammalian Hair BMC Evolutionary Biology · 2008
    20. Human Hair Keratin-Associated Proteins: Sequence Regularities and Structural Implications Journal of Structural Biology · 2006
    21. Human Hair Keratin-Associated Proteins International review of cytology · 2006
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    23. Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon Mammalian genome · 2004

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