TLDR Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.
The review article delves into the genetic complexity of keratin-associated protein (KRTAP) genes in sheep and goats, which are essential for wool and hair fiber properties. It highlights the identification of numerous unique KRTAPs in these animals, their genetic polymorphisms, and their impact on fiber traits like fineness and color. The study reveals significant sequence variations, including SNPs and indels, and notes the uneven chromosomal distribution and transcriptional directions of KRTAPs. The findings underscore the genetic diversity and evolutionary divergence of KRTAPs in sheep and goats compared to humans, suggesting future research to further understand these genes' structure, function, and implications for breeding and textile industries.
Cited in this study
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6 citations
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February 2021 in “Proteins” Researchers found that the most reachable bonds in wool fibers are near the ends of certain proteins, which help stabilize the fiber's structure.
7 citations
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July 2019 in “Animals” The KRTAP21-1 gene affects wool yield and can help improve wool production.
42 citations
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January 2017 in “Genes” The gene KAP22-1 affects wool yield and fiber shape in sheep.
35 citations
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May 2014 in “Journal of proteomics” Feed restriction in sheep leads to finer wool fibers but may reduce wool quality.
51 citations
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May 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
53 citations
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June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” KAP genes show significant genetic variability, but its impact on hair traits is unclear.
100 citations
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December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
98 citations
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June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” A cluster of sulfur-rich hair protein genes was found on chromosome 17.
67 citations
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December 1990 in “The journal of cell biology/The Journal of cell biology” Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.