The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes

November 2021 in “ International journal of molecular sciences ”

Huitong Zhou, Hua Gong, Jiqing Wang, Yuzhu Luo, Shaobin Li, Jinzhong Tao, Jonathan G. H. Hickford

keratin-associated protein KRTAP genetic polymorphisms SNPs indels chromosomal distribution transcriptional directions genetic diversity evolutionary divergence single nucleotide polymorphisms insertions and deletions

TLDR Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.

The review article delves into the genetic complexity of keratin-associated protein (KRTAP) genes in sheep and goats, which are essential for wool and hair fiber properties. It highlights the identification of numerous unique KRTAPs in these animals, their genetic polymorphisms, and their impact on fiber traits like fineness and color. The study reveals significant sequence variations, including SNPs and indels, and notes the uneven chromosomal distribution and transcriptional directions of KRTAPs. The findings underscore the genetic diversity and evolutionary divergence of KRTAPs in sheep and goats compared to humans, suggesting future research to further understand these genes' structure, function, and implications for breeding and textile industries.

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